Reaction: L-arginine + L-valine = N-amidino-L-valine + L-ornithine
Other name(s): ktmE (gene name); st-amdT (gene name)
Systematic name: L-arginine:L-valine amidinotransferase
Comments: The enzyme, characterized from the bacterium Salinispora tropica, participates in the biosynthesis of ketomemicins. In vitro the enzyme could use multiple other amino acids, including L-cysteine, L-isoleucine, L-leucine, L-methionine, L-tyrosine, L-phenylalanine and L-tryptophan instead of L-valine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Ogasawara, Y., Fujimori, M., Kawata, J. and Dairi, T. Characterization of three amidinotransferases involved in the biosynthesis of ketomemicins. Bioorg. Med. Chem. Lett. 26 (2016) 3662-3664. [PMID: 27289319]