IUBMB Enzyme Nomenclature


Accepted name: 6-deoxy-5-ketofructose 1-phosphate synthase

Reaction: (1) methylglyoxal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
(2) methylglyoxal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

For diagram of reaction click here.

Glossary: methylglyoxal = 2-oxopropanal
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 6-deoxy-5-ketofructose 1-phosphate

Other name(s): DKFP synthase; MJ1585 (gene name)

Systematic name: 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase

Comments: The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC, fructose-bisphosphate aldolase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. White, R.H. and Xu, H. Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii. Biochemistry 45 (2006) 12366-12379. [PMID: 17014089]

2. Samland, A.K., Wang, M. and Sprenger, G.A. MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity. FEMS Microbiol. Lett. 281 (2008) 36-41. [PMID: 18318840]

[EC created 2012]

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