IUBMB Enzyme Nomenclature


Accepted name: fluorothreonine transaldolase

Reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine

Systematic name: fluoroacetaldehyde:L-threonine aldehydetransferase

Comments: A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into 4-chloro-L-threonine. Unlike EC, glycine hydroxymethyltransferase, does not use glycine as a substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 403503-13-9


1. Murphy, C.D., O'Hagan, D. and Schaffrath, C. Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya. Angew. Chem. Int. Ed. Engl. 40 (2001) 4479-4481. [PMID: 12404452]

2. Murphy, C.D., Schaffrath, C. and O'Hagan, D. Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Chemosphere 52 (2003) 455-461. [PMID: 12738270]

[EC created 2003]

Return to EC 2.2.1 home page
Return to EC 2.2 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page