IUBMB Enzyme Nomenclature


Accepted name: acridone synthase

Reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2

For diagram click here.

Systematic name: malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)

Comments: Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 99085-53-7


1. Baumert, A., Maier, W., Gröger, D. and Deutzmann, R. Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L. Z. Naturforsch. C: Biosci. 49 (1994) 26-32. [PMID: 8148006]

2. Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Gröger, D. Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures. Phytochemistry 32 (1993) 691-698.

3. Lukacin. R., Springob, K., Urbanke, C., Ernwein, C., Schröder, G., Schröder, J. and Matern, U. Native acridone synthases I and II from Ruta graveolens L. form homodimers. FEBS Lett. 448 (1999) 135-140. [PMID: 10217426]

4. Junghanns, K.T., Kneusel, R.E., Groger, D. and Matern, U. Differential regulation and distribution of acridone synthase in Ruta graveolens. Phytochemistry 49 (1998) 403-411. [PMID: 9747538]

[EC created 2002]

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