IUBMB Enzyme Nomenclature


Accepted name: 6'-deoxychalcone synthase

Reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O

For diagram click here.

Glossary: isoliquiritigenin = 4,2',4'-trihydroxychalcone
liquiritigenin = 7,4'-dihydroxyflavanone

Systematic name: malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)

Comments: Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 114308-23-5


1. Ayabe, S., Udagawa, A. and Furuya, T. NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. Arch. Biochem. Biophys. 261 (1988) 458-462. [PMID: 3355160]

[EC created 2004]

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