Reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O
For diagram click here.
Glossary: isoliquiritigenin = 4,2',4'-trihydroxychalcone
liquiritigenin = 7,4'-dihydroxyflavanone
Systematic name: malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)
Comments: Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 114308-23-5
References:
1. Ayabe, S., Udagawa, A. and Furuya, T. NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. Arch. Biochem. Biophys. 261 (1988) 458-462. [PMID: 3355160]