Reaction: acetyl-CoA + phosphinothricin = CoA + N-acetylphosphinothricin
Glossary: phosphinothricin = glufosinate = 2-amino-4-[hydroxy(methyl)phosphoryl]butanoate
Other name(s): PAT; PPT acetyltransferase; Pt-N-acetyltransferase; ac-Pt
Systematic name: acetyl-CoA:phosphinothricin N-acetyltransferase
Comments: The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2, glutamate—ammonia ligase, a key enzyme of nitrogen metabolism in plants [2].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
References:
1. Botterman, J., Gosselé, V., Thoen, C. and Lauwereys, M. Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins. Gene 102 (1991) 33-37. [PMID: 1864506]
2. Dröge-Laser, W., Siemeling, U., Pühler, A. and Broer, I. The metabolites of the herbicide L-phosphinothricin (glufosinate) (identification, stability, and mobility in transgenic, herbicide-resistant, and untransformed plants). Plant Physiol. 105 (1994) 159-166. [PMID: 12232195]