IUBMB Enzyme Nomenclature


Accepted name: acetoacetyl-CoA synthase

Reaction: acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2

Other name(s): NphT7

Systematic name: acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating)

Comments: The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway. Unlike the homologous EC (β-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Okamura, E., Tomita, T., Sawa, R., Nishiyama, M. and Kuzuyama, T. Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. Proc. Natl. Acad. Sci. USA 107 (2010) 11265-11270. [PMID: 20534558]

[EC created 2011]

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