Reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate
Other name(s): sn-2-glycerol-3-phosphate O-acyltransferase; glycerol-3-phosphate O-acyltransferase (ambiguous)
Systematic name: acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase
Comments: A membrane-associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with ω-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Yang, W., Pollard, M., Li-Beisson, Y., Beisson, F., Feig, M. and Ohlrogge, J. A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol. Proc. Natl. Acad. Sci. USA 107 (2010) 12040-12045. [PMID: 20551224]