IUBMB Enzyme Nomenclature


Accepted name: protein S-acyltransferase

Reaction: palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA

Other name(s): DHHC palmitoyl transferase; S-protein acyltransferase; G-protein palmitoyltransferase

Systematic name: palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase

Comments: The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, PDB, CAS registry number:


1. Dunphy, J.T., Greentree, W.K., Manahan, C.L. and Linder, M.E. G-protein palmitoyltransferase activity is enriched in plasma membranes. J. Biol. Chem. 271 (1996) 7154-7159. [PMID: 8636152]

2. Veit, M., Dietrich, L.E. and Ungermann, C. Biochemical characterization of the vacuolar palmitoyl acyltransferase. FEBS Lett 540 (2003) 101-105. [PMID: 12681491]

3. Batistic, O. Genomics and localization of the Arabidopsis DHHC-cysteine-rich domain S-acyltransferase protein family. Plant Physiol. 160 (2012) 1597-1612. [PMID: 22968831]

4. Jennings, B.C. and Linder, M.E. DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities. J. Biol. Chem. 287 (2012) 7236-7245. [PMID: 22247542]

5. Zhou, L.Z., Li, S., Feng, Q.N., Zhang, Y.L., Zhao, X., Zeng, Y.L., Wang, H., Jiang, L. and Zhang, Y. Protein S-acyl transferase10 is critical for development and salt tolerance in Arabidopsis. Plant Cell 25 (2013) 1093-1107. [PMID: 23482856]

[EC created 2013]

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