IUBMB Enzyme Nomenclature


Accepted name: isovaleryl-homoserine lactone synthase

Reaction: isovaleryl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone

Glossary: S -methyl-5'-thioadenosine = 5'-deoxy-5'-(methylsulfanyl)adenosine

Other name(s): IV-HSL synthase; BjaI

Systematic name: isovaleryl-CoA:S-adenosyl-L-methionine isovaleryltranserase (lactone-forming, methylthioadenosine-releasing)

Comments: The enzyme, found in the bacterium Bradyrhizobium japonicum, does not accept isovaleryl-[acyl-carrier protein] as acyl donor (cf. EC, acyl-homoserine-lactone synthase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Lindemann, A., Pessi, G., Schaefer, A.L., Mattmann, M.E., Christensen, Q.H., Kessler, A., Hennecke, H., Blackwell, H.E., Greenberg, E.P. and Harwood, C.S. Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. Proc. Natl. Acad. Sci. USA 108 (2011) 16765-16770. [PMID: 21949379]

[EC created 2013]

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