IUBMB Enzyme Nomenclature


Accepted name: 4-coumaroyl-homoserine lactone synthase

Reaction: 4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone

Glossary: S -methyl-5'-thioadenosine = 5'-deoxy-5'-(methylsulfanyl)adenosine

Other name(s): p-coumaryl-homoserine lactone synthase; RpaI

Systematic name: 4-coumaroyl-CoA:S-adenosyl-L-methionine trans-4-coumaroyltranserase (lactone-forming, methylthioadenosine-releasing)

Comments: The enzyme is found in the bacterium Rhodopseudomonas palustris, which produces N-(4-coumaroyl)-L-homoserine lactone as a quorum-sensing signal.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Schaefer, A.L., Greenberg, E.P., Oliver, C.M., Oda, Y., Huang, J.J., Bittan-Banin, G., Peres, C.M., Schmidt, S., Juhaszova, K., Sufrin, J.R. and Harwood, C.S. A new class of homoserine lactone quorum-sensing signals. Nature 454 (2008) 595-599. [PMID: 18563084]

[EC created 2013]

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