IUBMB Enzyme Nomenclature


Accepted name: methanol O-anthraniloyltransferase

Reaction: anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate

Glossary: anthraniloyl-CoA = 2-aminobenzoyl-CoA

Other name(s): AMAT; anthraniloyl-coenzyme A (CoA):methanol acyltransferase

Systematic name: anthraniloyl-coenzyme A:methanol O-anthraniloyltransferase

Comments: The enzyme from Concord grape (Vitis labrusca) is solely responsible for the production of O-methyl anthranilate, an important aroma and flavor compound in the grape. The enzyme has a broad substrate specificity, and can use a range of alcohols with substantial activity, the best being butanol, benzyl alcohol, iso-pentanol, octanol and 2-propanol. It can use benzoyl-CoA and acetyl-CoA as acyl donors with lower efficiency. In addition to O-methyl anthranilate, the enzyme might be responsible for the production of ethyl butanoate, methyl-3-hydroxy butanoate and ethyl-3-hydroxy butanoate, which are present in large quantities in the grapes. Also catalyses EC, benzyl alcohol O-benzoyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Wang, J. and De Luca, V. The biosynthesis and regulation of biosynthesis of Concord grape fruit esters, including ’foxy’ methylanthranilate. Plant J. 44 (2005) 606-619. [PMID: 16262710]

[EC created 2014]

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