IUBMB Enzyme Nomenclature


Accepted name: (aminoalkyl)phosphonate N-acetyltransferase

Reaction: acetyl-CoA + (aminomethyl)phosphonate = CoA + (acetamidomethyl)phosphonate

Other name(s): phnO (gene name)

Systematic name: acetyl-CoA:(aminomethyl)phosphonate N-acetyltransferase

Comments: The enzyme, characterized from the bacterium Escherichia coli, is able to acetylate a range of (aminoalkyl)phosphonic acids. Requires a divalent metal ion for activity.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Errey, J.C. and Blanchard, J.S. Functional annotation and kinetic characterization of PhnO from Salmonella enterica. Biochemistry 45 (2006) 3033-3039. [PMID: 16503658]

2. Hove-Jensen, B., McSorley, F.R. and Zechel, D.L. Catabolism and detoxification of 1-aminoalkylphosphonic acids: N-acetylation by the phnO gene product. PLoS One 7 (2012) e46416. [PMID: 23056305]

[EC created 2018]

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