IUBMB Enzyme Nomenclature


Accepted name: acetyl-CoA:lysine N6-acetyltransferase

Reaction: acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine

Other name(s): LYC1 (gene name); lysine N6-acetyltransferase (ambiguous)

Systematic name: acetyl-CoA:L-lysine N6-acetyltransferase

Comments: The enzyme catalyses the first step of an L-lysine degradation pathway found in many fungal species. The enzyme is specific for acetyl-CoA as the acetyl donor. cf. EC, lysine N-acetyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Schmidt, H., Bode, R., and Birnbaum , D. Lysine degradation in Candida maltosa: occurrence of a novel enzyme, acetyl-CoA: L-lysine N-acetyltransferase. Arch. Microbiol. 150 (1988) 215-218.

2. Large, P.J. and Robertson, A. The route of lysine breakdown in Candida tropicalis, FEMS Microbiol. Lett. 66 (1991) 209-213. [PMID: 1682209]

3. Bode, R., Thurau, A.M. and Schmidt, H. Characterization of acetyl-CoA: L-lysine N6-acetyltransferase, which catalyses the first step of carbon catabolism from lysine in Saccharomyces cerevisiae, Arch. Microbiol. 160 (1993) 397-400. [PMID: 8257283]

4. Beckerich, J.M., Lambert, M. and Gaillardin, C. LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast. Curr. Genet. 25 (1994) 24-29. [PMID: 8082161]

[EC created 2021]

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