IUBMB Enzyme Nomenclature


Accepted name: tubulin N-terminal N-acetyltransferase NAT9

Reaction: acetyl-CoA + an N-terminal-L-methionyl-[tubulin] = an N-terminal-Nα-acetyl-L-methionyl-[tubulin] + CoA

Other name(s): NAT9 (gene name); microtubule-associated N-acetyltransferase NAT9

Systematic name: acetyl-CoA:N-terminal-Met-[tubulin] Met-Nα-acetyltransferase

Comments: The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both α- and β-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin α/β heterodimer.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Mok, J.W. and Choi, K.W. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Proc. Natl. Acad. Sci. USA 118 (2021) . [PMID: 33479178]

[EC created 2022]

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