Reaction: 3-dehydrocarnitine + acetyl-CoA = acetoacetate + betainyl-CoA
Other name(s): cdhC (gene name); 3-dehydrocarnitine cleavage enzyme
Systematic name: 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase
Comments: The enzyme, characterized from Pseudomonas aeruginosa and other bacteria, belongs to a class of enzymes known as β-keto acid cleavage enzymes (BKACE). It participates in an L-carnitine degradation pathway. cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Wargo, M.J. and Hogan, D.A. Identification of genes required for Pseudomonas aeruginosa carnitine catabolism. Microbiology (Reading) 155 (2009) 2411-2419. [PMID: 19406895]
2. Bastard, K., Smith, A.A., Vergne-Vaxelaire, C., Perret, A., Zaparucha, A., De Melo-Minardi, R., Mariage, A., Boutard, M., Debard, A., Lechaplais, C., Pelle, C., Pellouin, V., Perchat, N., Petit, J.L., Kreimeyer, A., Medigue, C., Weissenbach, J., Artiguenave, F., De Berardinis, V., Vallenet, D. and Salanoubat, M. Revealing the hidden functional diversity of an enzyme family. Nat. Chem. Biol. 10 (2014) 42-49. [PMID: 24240508]