Reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + CoA
Glossary: (3R)-3-amino-3-phenylpropanoyl-CoA = (3R)-β-phenylalanyl-CoA
Other name(s): BAPT; baccatin III:3-amino-3-phenylpropanoyltransferase; baccatin III-3-amino-13-phenylpropanoyltransferase; 3'-N-de-benzoyl-2'-deoxytaxol-N-benzoyltransferase
Systematic name: (3R)-3-amino-3-phenylpropanoyl-CoA:baccatin III C-13 O-((3R)-3-amino-3-phenylpropanoyl)transferase
Comments: The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Walker, K., Fujisaki, S., Long, R. and Croteau, R. Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis. Proc. Natl. Acad. Sci. USA 99 (2002) 12715-12720. [PMID: 12232048]