Reaction: benzoyl-CoA + 3'-N-debenzoyltaxol = CoA + paclitaxel
Other name(s): DBTNBT; 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase
Systematic name: benzoyl-CoA:3'-N-debenzoyltaxol 3'-N-benzoyltransferase
Comments: The enzyme, present in Taxus species (yew) catalyses the final step in paclitaxel (Taxol) biosynthesis
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Walker, K., Long, R. and Croteau, R. The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. Proc. Natl. Acad. Sci. USA 99 (2002) 9166-9171. [PMID: 12089320]
2. Long, R.M., Lagisetti, C., Coates, R.M. and Croteau, R.B. Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis. Arch. Biochem. Biophys. 477 (2008) 384-389. [PMID: 18621016]
3. Zhang, Y., Wiese, L., Fang, H., Alseekh, S., Perez de Souza, L., Scossa, F., Molloy, J., Christmann, M. and Fernie, A.R. Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis. Mol. Plant 16 (2023) 1951-1961. [PMID: 37897038]