Reaction: acetyl-CoA + L-phenylglycine = (2S)-2-acetylamino-2-phenylacetic acid + CoA
Other name(s): natA (gene name)
Systematic name: acetyl-CoA:L-phenylgylcine N-acetyltransferase
Comments: The enzyme has been isolated from the bacterium Chryseobacterium sp. 5-3B. Reduced activity has been observed with L-2-phenylglycine methyl ester, L-2-chlorophenylglycine and L-4-hydroxyphenylglycine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Takenaka, S., Honma, Y., Yoshida, K. and Yoshida, K. Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp. Biotechnol. Lett. 35 (2013) 1053-1059. [PMID: 23479412]
2. Takenaka, S., Yoshida, K., Tanaka, K. and Yoshida, K. Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp. Appl. Environ. Microbiol. 80 (2014) 1770-1776. [PMID: 24375143]
3. Takenaka, S., Ozeki, T., Tanaka, K. and Yoshida, K.I. Homology modeling and prediction of the amino acid residues participating in the transfer of acetyl-CoA to arylalkylamine by the N-acetyltransferase from Chryseobacterium sp. Biotechnol. Lett. 39 (2017) 1699-1707. [PMID: 28721586]