Reaction: (1) glycocholate + an L-amino acid = an amino acid—bile acid amidate + glycine
(2) taurocholate + an L-amino acid = an amino acid—bile acid amidate + taurine
Other name(s): bsh (gene name)
Systematic name: conjugated bile acid:L-amino acid N-acyltransferase
Comments: Amino acid—bile acid amidates are formed in the gastrointestinal tract from bile acid conjugates of glycine or taurine. This is a second activity of the bacterial enzyme EC 3.5.1.24, choloylglycine hydrolase (also known as bile salt hydrolase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Rimal, B., Collins, S.L., Tanes, C.E., Rocha, E.R., Granda, M.A., Solanki, S., Hoque, N.J., Gentry, E.C., Koo, I., Reilly, E.R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M.S., Bittinger, K., Zackular, J.P., Krausz, K.W., Desai, D., Amin, S., Coleman, J.P., Shah, Y.M., Bisanz, J.E., Gonzalez, F.J., Vanden Heuvel, J.P., Wu, G.D., Zemel, B.S., Dorrestein, P.C., Weinert, E.E. and Patterson, A.D. Bile salt hydrolase catalyses formation of amine-conjugated bile acids. Nature 626 (2024) 859-863. [PMID: 38326609]