IUBMB Enzyme Nomenclature


Accepted name: serine C-palmitoyltransferase

Reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2

Other name(s): serine palmitoyltransferase; SPT; 3-oxosphinganine synthetase; acyl-CoA:serine C-2 acyltransferase decarboxylating

Systematic name: palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

Comments: A pyridoxal-phosphate protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 62213-50-7


1. Brady, R.N., DiMari, S.J. and Snell, E.E. Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri. J. Biol. Chem. 244 (1969) 491-496. [PMID: 4388074]

2. Stoffel, W., Le Kim, D. and Sticht, G. Biosynthesis of dihydrosphingosine in vitro. Hoppe-Seyler's Z. Physiol. Chem. 349 (1968) 664-670. [PMID: 4386961]

[EC created 1976, modified 1982]

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