Reaction: acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a
Glossary: kanamycin
Other name(s): gentamycin acetyltransferase II; acetyl-CoA:gentamycin-C1a N2'-acetyltransferase; gentamycin 2'-N-acetyltransferase; acetyl-CoA:gentamycin-C1a N2'-acetyltransferase
Systematic name: acetyl-CoA:gentamicin-C1a N2'-acetyltransferase
Comments: The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 50864-40-9
References:
1. Benveniste, R. and Davies, J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc. Natl. Acad. Sci. USA 70 (1973) 2276-2280. [PMID: 4209515]