EC 2.3.1.60

Reaction: acetyl-CoA + gentamicin C = CoA + N³-acetylgentamicin C

Other name(s): gentamycin acetyltransferase I; aminoglycoside acetyltransferase AAC(3)-1; gentamycin 3-N-acetyltransferase; acetyl-CoA:gentamycin-C N³-acetyltransferase; acetyl-CoA:gentamicin-C N^3'-acetyltransferase (incorrect); gentamicin 3'-N-acetyltransferase (incorrect)

Systematic name: acetyl-CoA:gentamicin-C N³-acetyltransferase

Comments: Also acetylates sisomicin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 58500-58-6

References:

1. Angelatou, F., Litsas, S.B. and Kontomichalou, P. Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. J. Antibiot. 35 (1982) 235-244. [PMID: 6281224]

2. Biddlecome, S., Haas, J., Davies, G.H., Miller, D., Rane, F. and Daniels, P.J.L. Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob. Agents Chemother. 9 (1976) 951-955. [PMID: 820250]

3. Williams, J.W. and Northrop, D.B. Purification and properties of gentamicin acetyltransferase I. Biochemistry 15 (1976) 125-131. [PMID: 764855]