IUBMB Enzyme Nomenclature


Accepted name: fatty-acyl-CoA synthase system

Reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+

Other name(s): yeast fatty acid synthase; FAS1 (gene name); FAS2 (gene name); fatty-acyl-CoA synthase

Systematic name: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)

Comments: The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC, 3-oxoacyl-[acyl-carrier-protein] reductase and EC, β-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC, [acyl-carrier-protein] S-acetyltransferase, EC, [acyl-carrier-protein] S-malonyltransferase, EC, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme system differs from the animal system (EC, fatty-acid synthase system) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, PDB, CAS registry number: 94219-29-1


1. Schweitzer, E., Kniep, B., Castorph, H. and Holzner, U. Pantetheine-free mutants of the yeast fatty-acid-synthetase complex. Eur. J. Biochem. 39 (1973) 353-362. [PMID: 4590449]

2. Wakil, S.J., Stoops, J.K. and Joshi, V.C. Fatty acid synthesis and its regulation. Annu. Rev. Biochem. 52 (1983) 537-579. [PMID: 6137188]

3. Tehlivets, O., Scheuringer, K. and Kohlwein, S.D. Fatty acid synthesis and elongation in yeast. Biochim. Biophys. Acta 1771 (2007) 255-270. [PMID: 16950653]

[EC created 1984, modified 2003, modified 2013, modified 2019]

Return to EC 2.3.1 home page
Return to EC 2.3 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page