Reaction: (3R)-3-methyl-L-phenylalanyl-[peptidyl carrier-protein] + SB-203207 = [peptidyl carrier-protein] + SB-203208
Glossary: SB-203207 = (sulfonamide-N)(L-isoleucyl)altemidicin = (4aR,6S,7R,7aS)-4-(carbamoyl)-7-({[(2S,3S)-2-amino-3-methylpentanoyl]aminosulphonyl}acetamido)-6-hydroxy-2-methyl-1,4a,5,6,7,7a-hexahydro-2H-cyclopenta[c]pyrindine-7-carboxylate
SB-203208 = (4aR,6S,7R,7aS)-4-(carbamonyl)-7-({[(2S,3S)-2-amino-3-methylpentanoyl]-aminosulphonyl}acetamido)-6-{[(2S,3S)-2-amino-3-phenylbutanoyl]oxy}-2-methyl-1,4a,5,6,7,7a-hexahydro-2H-cyclopents[c]pyrindine-7-carboxylate
Other name(s): sbzC (gene name)
Systematic name: (3R)-3-methyl-L-phenylalanyl-[peptidyl carrier-protein]:SB-20307 O-(3R)-3-methyl-L-phenylalanyl-transferase
Comments: The enzyme, characterized from the bacterium Streptomyces sioyaensis, catalyses the last step in the biosynthesis of the monoterpene alkaloid SB-203208.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Hu, Z., Awakawa, T., Ma, Z. and Abe, I. Aminoacyl sulfonamide assembly in SB-203208 biosynthesis. Nat. Commun. 10 (2019) 184. [PMID: 30643149]