IUBMB Enzyme Nomenclature


Accepted name: citrate (Re)-synthase

Reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA

For diagram click here.

Other name(s): (R)-citrate synthase; Re-citrate-synthase; citrate oxaloacetate-lyase [(pro-3R)-CH2COO-→acetyl-CoA]

Systematic name: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]

Comments: This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC, citrate (Si)-synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9077-70-7


1. Dittbrenner, S., Chowdhury, A.A. and Gottschalk, G. The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate. Biochem. Biophys. Res. Commun. 36 (1969) 802-808. [PMID: 5808294]

2. Gottschalk, G. Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici. Eur. J. Biochem. 7 (1969) 301-306. [PMID: 4974734]

3. Gottschalk, G. and Barker, H.A. Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase. Biochemistry 5 (1966) 1125-1133. [PMID: 5958189]

[EC created 1972 as EC, transferred 2002 to EC]

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