IUBMB Enzyme Nomenclature


Accepted name: decylhomocitrate synthase

Reaction: dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA

For diagram click here.

Other name(s): 2-decylhomocitrate synthase; 3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)

Systematic name: dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)

Comments: Decanoyl-CoA can act instead of dodecanoyl-CoA, but 2-oxoglutarate cannot be replaced by oxaloacetate or pyruvate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 51845-40-0


1. Måhlén, A. Purification and some properties of 2-decylhomocitrate synthase from Penicillium spiculisporum. Eur. J. Biochem. 38 (1973) 32-39. [PMID: 4774124]

2. Brandäge, S., Dahlman, O., Lindqvist, B., Måhlén, A. and Mörch, L. Absolute configuration and enantiospecific synthesis of spiculisporic acid. Acta Chem. Scand. 38B (1984) 837-844.

[EC created 1976 as EC, transferred 2002 to EC]

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