IUBMB Enzyme Nomenclature


Accepted name: malate synthase

Reaction: acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA

For diagram of reaction click here.

Other name(s): L-malate glyoxylate-lyase (CoA-acetylating); glyoxylate transacetylase; glyoxylate transacetase; glyoxylic transacetase; malate condensing enzyme; malate synthetase; malic synthetase; malic-condensing enzyme; acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Systematic name: acetyl-CoA:glyoxylate C-acetyltransferase [(S)-malate-forming]

Comments: The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9013-48-3


1. Dixon, G.H., Kornberg, H.L. and Lund, P. Purification and properties of malate synthetase. Biochim. Biophys. Acta 41 (1960) 217-233. [PMID: 13816984]

[EC created 1961 as EC, transferred 2002 to EC]

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