Reaction: UDP-α-D-glucose + [(1→4)-α-D-glucosyl]n = UDP + [(1→4)-α-D-glucosyl]n+1
For diagram of reaction click here
Other name(s): UDP-glucoseglycogen glucosyltransferase; glycogen (starch) synthetase; UDP-glucose-glycogen glucosyltransferase; UDP-glycogen synthase; UDPG-glycogen synthetase; UDPG-glycogen transglucosylase; uridine diphosphoglucose-glycogen glucosyltransferase
Systematic name: UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase (configuration-retaining)
Comments: The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 188.8.131.52, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 184.108.40.206 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 220.127.116.11, starch synthase).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9014-56-6
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2. Basu, D.K. and Bachhawat, B.K. Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain. Biochim. Biophys. Acta 50 (1961) 123-128. [PMID: 13687710]
3. Leloir, L.F. and Cardini, C.E. UDPG-glycogen transglucosylase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 6, Academic Press, New York, 1962, pp. 317-326.
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