IUBMB Enzyme Nomenclature


Accepted name: tRNA-queuosine α-mannosyltransferase

Reaction: GDP-α-D-mannose + queuosine34 in tRNAAsp = GDP + O-4''-α-D-mannosylqueuosine34 in tRNAAsp

Other name(s): GDP-mannose:tRNAAsp-queuosine O-5''-β-D-mannosyltransferase (incorrect); tRNA-queuosine β-mannosyltransferase (incorrect)

Systematic name: GDP-α-D-mannose:queuosine34 in tRNAAsp O-4''-α-D-mannosyltransferase (configuration-retaining)

Comments: This enzyme, found in higher vertebrates, modifies tRNAAsp at the wobble position of the anticodon loop.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9055-06-5


1. Okada, N. and Nishimura, S. Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver. Nucleic Acids Res. 4 (1977) 2931-2938. [PMID: 20603]

2. Hillmeier, M., Wagner, M., Ensfelder, T., Korytiakova, E., Thumbs, P., Muller, M. and Carell, T. Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine. Nat. Commun. 12 (2021) 7123. [PMID: 34880214]

[EC created 1984, modified 2022]

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