IUBMB Enzyme Nomenclature


Accepted name: mannosyl-3-phosphoglycerate synthase

Reaction: GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(α-D-mannosyl)-3-phosphoglycerate

Other name(s): MPG synthase; GDP-mannose:3-phosphoglycerate 3-α-D-mannosyltransferase

Systematic name: GDP-mannose:3-phospho-D-glycerate 3-α-D-mannosyltransferase

Comments: Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 393512-63-5


1. Empadinhas, N., Marugg, J.D., Borges, N., Santos, H. and da Costa, M.S. Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key-enzymes. J. Biol. Chem. 276 (2001) 43580-43588. [PMID: 11562374]

[EC created 2002]

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