IUBMB Enzyme Nomenclature


Accepted name: chalcone 4'-O-glucosyltransferase

Reaction: (1) UDP-α-D-glucose + naringenin chalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-β-D-glucoside
(2) UDP-α-D-glucose + 2',3,4,4',6'-pentahydroxychalcone = UDP + 2',3,4,4',6'-pentahydroxychalcone 4'-O-β-D-glucoside

For diagram of reaction click here.

Glossary: 2',4,4',6'-tetrahydroxychalcone = 3-(4-hydroxyphemyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one

Other name(s): 4’CGT

Systematic name: UDP-α-D-glucose:2',4,4',6'-tetrahydroxychalcone 4'-O-β-D-glucosyltransferase

Comments: Isolated from the plant Antirrhinum majus (snapdragon). Involved in the biosynthesis of aurones, plant flavonoids that provide yellow color to the flowers.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Ono, E., Fukuchi-Mizutani, M., Nakamura, N., Fukui, Y., Yonekura-Sakakibara, K., Yamaguchi, M., Nakayama, T., Tanaka, T., Kusumi, T. and Tanaka, Y. Yellow flowers generated by expression of the aurone biosynthetic pathway. Proc. Natl. Acad. Sci. USA 103 (2006) 11075-11080. [PMID: 16832053]

[EC created 2012]

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