IUBMB Enzyme Nomenclature

EC 2.4.1.310

Accepted name: vancomycin aglycone glucosyltransferase

Reaction: UDP-α-D-glucose + vancomycin aglycone = UDP + devancoaminyl-vancomycin

For diagram of reaction, click here

Glossary: desvancoaminyl-vancomycin = vancomycin pseudoaglycone

Other name(s): GtfB (ambiguous)

Systematic name: UDP-α-D-glucose:vancomycin aglycone 48-O-β-glucosyltransferase

Comments: The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745-4755. [PMID: 11294642]

2. Mulichak, A.M., Losey, H.C., Walsh, C.T. and Garavito, R.M. Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. Structure 9 (2001) 547-557. [PMID: 11470430]

[EC 2.4.1.310 created 2013]


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