IUBMB Enzyme Nomenclature


Accepted name: demethyllactenocin mycarosyltransferase

Reaction: dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin

For diagram of reaction click here.

Glossary: dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside

Other name(s): tylCV (gene name); tylC5 (gene name)

Systematic name: dTDP-β-L-mycarose:demethyllactenocin 4'-O-α-L-mycarosyltransferase

Comments: The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Bate, N., Butler, A.R., Smith, I.P. and Cundliffe, E. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. Microbiology 146 (2000) 139-146. [PMID: 10658660]

[EC created 2014]

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