IUBMB Enzyme Nomenclature


Accepted name: ginsenoside F1 6-O-glucosyltransferase

Reaction: UDP-α-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1

For diagram of reaction click here

Glossary: ginsenoside F1 = 3β,6α,12β-trihydroxydammar-24-en-20-yl β-D-glucopyranoside

Other name(s): UGTPg101 (gene name)

Systematic name: UDP-α-D-glucose:ginsenoside F1 6-O-glucosyltransferase

Comments: The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC, ginsenoside 20-O-glucosyltransferase). However, unlike EC, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Wei, W., Wang, P., Wei, Y., Liu, Q., Yang, C., Zhao, G., Yue, J., Yan, X. and Zhou, Z. Characterization of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts. Mol. Plant 8 (2015) 1412-1424. [PMID: 26032089]

[EC created 2019]

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