Reaction: GDP-α-D-mannose + [(1→2)-β-D-mannosyl]n = GDP + [(1→2)-β-D-mannosyl]n+1
Other name(s): MTP1 (gene name); MTP2 (gene name)
Systematic name: GDP-α-D-mannose:(1→2)-β-D-mannan mannosyltransferase (configuration-inverting)
Comments: The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a β-(1→2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Sernee, M.F., Ralton, J.E., Nero, T.L., Sobala, L.F., Kloehn, J., Vieira-Lara, M.A., Cobbold, S.A., Stanton, L., Pires, D.EV., Hanssen, E., Males, A., Ward, T., Bastidas, L.M., van der Peet, P.L., Parker, M.W., Ascher, D.B., Williams, S.J., Davies, G.J. and McConville, M.J. A family of dual-activity glycosyltransferase-phosphorylases mediates mannogen turnover and virulence in Leishmania parasites. Cell Host Microbe 26 (2019) 385-399.e9. [PMID: 31513773]