IUBMB Enzyme Nomenclature


Accepted name: neamine phosphoribosyltransferase

Reaction: neamine + 5-phospho-α-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate

For diagram of reaction click here.

Glossary: neamine = (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}oxane-3,4-diol
ribostamycin = (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol

Other name(s): btrL (gene name); neoM (gene name)

Systematic name: neamine:5-phospho-α-D-ribose 1-diphosphate phosphoribosyltransferase

Comments: Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg2+, Ni2+ or Co2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kudo, F., Fujii, T., Kinoshita, S. and Eguchi, T. Unique O-ribosylation in the biosynthesis of butirosin. Bioorg. Med. Chem. 15 (2007) 4360-4368. [PMID: 17482823]

[EC created 2013]

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