IUBMB Enzyme Nomenclature


Accepted name: adenine phosphoribosyltransferase

Reaction: AMP + diphosphate = adenine + 5-phospho-α-D-ribose 1-diphosphate

For diagram of reaction click here.

Other name(s): AMP pyrophosphorylase; transphosphoribosidase; APRT; AMP-pyrophosphate phosphoribosyltransferase; adenine phosphoribosylpyrophosphate transferase; adenosine phosphoribosyltransferase; adenylate pyrophosphorylase; adenylic pyrophosphorylase

Systematic name: AMP:diphosphate phospho-D-ribosyltransferase

Comments: 5-Amino-4-imidazolecarboxamide can replace adenine.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9027-80-9


1. Flaks, J.G., Erwin, M.J. and Buchanan, J.M. Biosynthesis of the purines. XVI. The synthesis of adenosine 5'-phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase. J. Biol. Chem. 228 (1957) 201-213.

2. Kornberg, A., Lieberman, I. and Simms, E.S. Enzymatic synthesis of purine nucleotides. J. Biol. Chem. 215 (1955) 417-427.

3. Lukens, L.N. and Herrington, K.A. Enzymic formation of 6-mercaptopurine ribotide. Biochim. Biophys. Acta 24 (1957) 432-433.

[EC created 1961]

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