IUBMB Enzyme Nomenclature


Accepted name: geranyl-pyrophosphate—olivetolic acid geranyltransferase

Reaction: geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate

For diagram of reaction click here.

Glossary: 2,4-dihydroxy-6-pentylbenzoate = olivetolate
cannabigerolate = CBGA = 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4-dihydroxy-6-pentylbenzoate
cannabinerolate = 3-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-2,4-dihydroxy-6-pentylbenzoate

Other name(s): GOT (ambiguous)

Systematic name: geranyl-diphosphate:olivetolate geranyltransferase

Comments: Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Fellermeier, M. and Zenk, M.H. Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol. FEBS Lett 427 (1998) 283-285. [PMID: 9607329]

[EC created 2012]

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