IUBMB Enzyme Nomenclature


Accepted name: adenylate dimethylallyltransferase (ADP/ATP-dependent)

Reaction: (1) dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5′-diphosphate
(2) dimethylallyl diphosphate + ATP = diphosphate + N6-(dimethylallyl)adenosine 5′-triphosphate

For diagram of reaction, click here

Other name(s): cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT

Systematic name: dimethylallyl-diphosphate:ADP/ATP dimethylallyltransferase

Comments: Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP [1]. Other isoforms, such as IPT1 from Arabidopsis thaliana [1,2] and the enzyme from the common hop, Humulus lupulus [3], also have a lower activity with AMP (cf. EC, adenylate dimethylallyltransferase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Kakimoto, T. Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases. Plant Cell Physiol 42 (2001) 677-685. [PMID: 11479373]

2. Takei, K., Sakakibara, H. and Sugiyama, T. Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana. J. Biol. Chem. 276 (2001) 26405-26410. [PMID: 11313355]

3. Sakano, Y., Okada, Y., Matsunaga, A., Suwama, T., Kaneko, T., Ito, K., Noguchi, H. and Abe, I. Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.). Phytochemistry 65 (2004) 2439-2446. [PMID: 15381407]

[EC created 2013]

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