IUBMB Enzyme Nomenclature


Accepted name: 4-O-dimethylallyl-L-tyrosine synthase

Reaction: prenyl diphosphate + L-tyrosine = diphosphate + 4-O-prenyl-L-tyrosine

Other name(s): SirD; dimethylallyl diphosphate:L-tyrosine 4-O-dimethylallyltransferase

Systematic name: prenyl-diphosphate:L-tyrosine 4-O-prenyltransferase

Comments: The enzyme is involved in biosynthesis of the phytotoxin sirodesmin PL by the phytopathogenic ascomycete Leptosphaeria maculans.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kremer, A. and Li, S.M. A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL. Microbiology 156 (2010) 278-286. [PMID: 19762440]

2. Zou, H.X., Xie, X., Zheng, X.D. and Li, S.M. The tyrosine O-prenyltransferase SirD catalyzes O-, N-, and C-prenylations. Appl. Microbiol. Biotechnol. 89 (2011) 1443-1451. [PMID: 21038099]

[EC created 2014]

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