Reaction: S-adenosyl-L-methionine + an N1-methyl-pseudouridine in rRNA = S-methyl-5'-thioadenosine + an N1-methyl-N3-[(3S)-3-aminocarboxypropyl]-pseudouridine in rRNA
Other name(s): TSR3 (gene name)
Systematic name: S-adenosyl-L-methionine:rRNA N1-pseudouridine 3-[(3S)-3-amino-3-carboxypropyl]transferase
Comments: The enzyme, found in all eukaryotes and some archaea, catalyses the final step in production of the modified rRNA nucleotide N1-methyl-N3-[(3S)-aminocarboxypropyl]-pseudouridine (m1acp3ψ). This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC 2.5.1.114, tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, and EC 2.5.1.108, 2-(3-amino-3-carboxypropyl)histidine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Meyer, B., Wurm, J.P., Sharma, S., Immer, C., Pogoryelov, D., Kotter, P., Lafontaine, D.L., Wohnert, J. and Entian, K.D. Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. Nucleic Acids Res. 44 (2016) 4304-4316. [PMID: 27084949]