Reaction: O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate
Other name(s): CGS1 (gene name)
Systematic name: O-phospho-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
Comments: A pyridoxal 5'-phosphate-dependent enzyme, found in plants, that participates in the plant L-methionine biosynthetic pathway. It differs from its bacterial counterpart, EC 2.5.1.48, cystathionine γ-synthase, in being specific for O-phospho-L-homoserine (the bacterial enzyme is specific for O-succinyl-L-homoserine).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Ravanel, S., Gakiere, B., Job, D. and Douce, R. Cystathionine γ-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli. Biochem. J. 331 (1998) 639-648. [PMID: 9531508]
2. Steegborn, C., Messerschmidt, A., Laber, B., Streber, W., Huber, R. and Clausen, T. The crystal structure of cystathionine γ-synthase from Nicotiana tabacum reveals its substrate and reaction specificity. J. Mol. Biol. 290 (1999) 983-996. [PMID: 10438597]
3. Clausen, T., Wahl, M.C., Messerschmidt, A., Huber, R., Fuhrmann, J.C., Laber, B., Streber, W. and Steegborn, C. Cloning, purification and characterisation of cystathionine γ-synthase from Nicotiana tabacum. Biol. Chem. 380 (1999) 1237-1242. [PMID: 10595588]