Reaction: S-adenosyl-L-methionine + L-histidine = N-[(3S)-3-amino-3-carboxypropyl]-L-histidine + S-methyl-5'-thioadenosine
Other name(s): cntL (gene name); smtA3 (gene name)
Systematic name: S-adenosyl-L-methionine:L-histidine N-[(3S)-3-amino-3-carboxypropyl]-transferase
Comments: The enzyme, characterized from the bactreria Pseudomonas aeruginosa and Yersinia pestis, is similar to EC 2.5.1.152, D-histidine 2-aminobutanoyltransferase, but is specific for L-histidine. The enzyme participates in the biosynthesis of the opine metallophores pseudopaline and yersinopine, respectively, in the two organisms.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. McFarlane, J.S. and Lamb, A.L. Biosynthesis of an opine metallophore by Pseudomonas aeruginosa. Biochemistry 56 (2017) 5967-5971. [PMID: 29091735]
2. McFarlane, J.S., Davis, C.L. and Lamb, A.L. Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase. J. Biol. Chem. 293 (2018) 8009-8019. [PMID: 29618515]