Reaction: thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole
For diagram click here.
Other name(s): pyrimidine transferase; thiaminase I; thiamin hydrolase; thiamin pyridinolase; thiaminase (ambiguous); thiamine pyridinolase; thiamin pyridinylase; thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Systematic name: thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Comments: Various bases and thiol compounds can act instead of pyridine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9030-35-7
References:
1. Fujita, A. Thiaminases. Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 389-421.
2. Kenten, R.H. The partial purification and properties of a thiaminase from bracken [Pteridium aquilinum (L.) Kuhn]. Biochem. J. 67 (1957) 25-33.
3. Wittliff, J.L. and Airth, R.L. The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties. Biochemistry 7 (1968) 736-744. [PMID: 4966932]