IUBMB Enzyme Nomenclature


Accepted name: thiamine pyridinylase

Reaction: thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole

For diagram click here.

Other name(s): pyrimidine transferase; thiaminase I; thiamin hydrolase; thiamin pyridinolase; thiaminase (ambiguous); thiamine pyridinolase; thiamin pyridinylase; thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase

Systematic name: thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase

Comments: Various bases and thiol compounds can act instead of pyridine.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9030-35-7


1. Fujita, A. Thiaminases. Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 389-421.

2. Kenten, R.H. The partial purification and properties of a thiaminase from bracken [Pteridium aquilinum (L.) Kuhn]. Biochem. J. 67 (1957) 25-33.

3. Wittliff, J.L. and Airth, R.L. The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties. Biochemistry 7 (1968) 736-744. [PMID: 4966932]

[EC created 1961, modified 1976, modified 2001]

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