Reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate
For diagram of reaction click here.
Glossary: O-acetyl-L-serine = (2S)-3-acetyloxy-2-aminopropanoic acid
Other name(s): β-(1-pyrazolyl)alanine synthase; β-pyrazolealanine synthase; β-pyrazolylalanine synthase (acetylserine); O3-acetyl-L-serine acetate-lyase (adding pyrazole); BPA-synthase; pyrazolealanine synthase; pyrazolylalaninase
Systematic name: O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase
Comments: The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37290-81-6
References:
1. Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y. Purification and characterization of β-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris. Phytochemistry 23 (1984) 973-977.
2. Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y. Purification and characterization of L-mimosine synthase from Leucaena leucocephala. Phytochemistry 23 (1984) 1905-1908.
3. Murakoshi, I., Kuramoto, H. and Haginiwa, J. The enzymic synthesis of β-substituted alanines. Phytochemistry 11 (1972) 177-182.
4. Noji, M., Murakoshi, I. and Saito K. Evidence for identity of β-pyrazolealanine synthase with cysteine synthase in watermelon: formation of β-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo. Biochem. Biophys. Res. Commun. 197 (1993) 1111-1117. [PMID: 8280125]