IUBMB Enzyme Nomenclature


Accepted name: methionine adenosyltransferase

Reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine

For diagram of reaction click here.

Other name(s): adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase

Systematic name: ATP:L-methionine S-adenosyltransferase

Comments: Formerly EC, methionine adenosyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9012-52-6


1. Cantoni, G.L. S-Adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosinetriphosphate. J. Biol. Chem. 204 (1953) 403-416.

2. Cantoni, G.L. and Durell, J. Activation of methionine for transmethylation. II. The methionine-activating enzyme: studies on the mechanism of reaction. J. Biol. Chem. 225 (1957) 1033-1048.

3. Mudd, S.H. and Cantoni, G.L. Activation of methionine for transmethylation. III. The methionine-activating enzyme of bakers' yeast. J. Biol. Chem. 231 (1958) 481-492.

[EC created 1961 as EC, transferred 1965 to EC]

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