Reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
For diagram of reaction click here.
Other name(s): adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase
Systematic name: ATP:L-methionine S-adenosyltransferase
Comments: Formerly EC 18.104.22.168, methionine adenosyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9012-52-6
1. Cantoni, G.L. S-Adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosinetriphosphate. J. Biol. Chem. 204 (1953) 403-416.
2. Cantoni, G.L. and Durell, J. Activation of methionine for transmethylation. II. The methionine-activating enzyme: studies on the mechanism of reaction. J. Biol. Chem. 225 (1957) 1033-1048.
3. Mudd, S.H. and Cantoni, G.L. Activation of methionine for transmethylation. III. The methionine-activating enzyme of bakers' yeast. J. Biol. Chem. 231 (1958) 481-492.