IUBMB Enzyme Nomenclature


Accepted name: N2-(2-carboxyethyl)arginine synthase

Reaction: D-glyceraldehdye 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate

For diagram click here.

Other name(s): CEAS; N2-(2-carboxyethyl)arginine synthetase; CEA synthetase

Systematic name: glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)

Comments: The enzyme requires thiamine diphosphate and catalyses the first step in the clavulanic-acid-biosynthesis pathway. The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 250207-48-8


1. Caines, M.E.C., Elkins, J.M., Hewitson, K.S. and Schofield, C.J. Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzymes in the clavulanic acid biosynthesis pathway. J. Biol. Chem. 279 (2004) 5685-5692. [PMID: 14623876]

2. Khaleeli, N., Li, R. and Townsend, C.A. Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction. J. Am. Chem. Soc. 121 (1999) 9223-9224.

[EC created 2004]

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