IUBMB Enzyme Nomenclature


Accepted name: (2Z,6E)-farnesyl diphosphate synthase

Reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate

For diagram of reaction, click here

Other name(s): (Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase

Systematic name: geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase

Comments: Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, PDB, CAS registry number:


1. Schulbach, M.C., Mahapatra, S., Macchia, M., Barontini, S., Papi, C., Minutolo, F., Bertini, S., Brennan, P.J. and Crick, D.C. Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis. J. Biol. Chem. 276 (2001) 11624-11630. [PMID: 11152452]

[EC created 2007, modified 2010]

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