IUBMB Enzyme Nomenclature


Accepted name: riboflavin synthase

Reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine

For diagram of reaction click here and mechanism (mechanism).

Other name(s): heavy riboflavin synthase; light riboflavin synthase; riboflavin synthetase; riboflavine synthase; riboflavine synthetase

Systematic name: 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase

Comments: A flavoprotein (riboflavin).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9075-82-5


1. Plaut, G.W.E. Studies on the nature of the enzymic conversion of 6,7-dimethyl-8-ribityllumazine to riboflavin. J. Biol. Chem. 238 (1963) 2225-2243.

2. Plaut, G.W.E. and Harvey, R.A. Riboflavin synthetase. Methods Enzymol. 18B (1971) 527-538.

3. Wacker, H., Harvey, R.A., Winestock, C.H. and Plaut, G.W.E. 4-(1'-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine, the second product of the riboflavin synthetase reaction. J. Biol. Chem. 239 (1964) 3493-3497.

[EC created 1972]

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